Abstract
Purpose: The present study aimed To investigate the neuroinhibitory and dysregulatory effects of lincomycin on visceral nervous regulation and gastrointestinal motor function via the gut-brain axis in a rat model.
Materials and Methods: Twenty adult white laboratory rats were orally administered lincomycin hydrochloride (84 ± 10 mg/kg/day) for 9 to 14 days. Morphological and neurophysiological parameters of the gastrointestinal tract were subsequently evaluated.
Results: Lincomycin treatment induced severe intestinal dysbiosis characterized by profound disruption of the microbial flora. Morphological examination revealed significant cecal enlargement and pronounced gaseous distension throughout the gastrointestinal tract. These structural alterations were accompanied by marked suppression of mesenteric neural responses and paradoxical hyperactivation of colonic contractile power, reflecting a segmental neural mismatch between the upper and lower gastrointestinal regions.
Conclusion: Lincomycin-induced dysbiosis drives pathological cecal expansion and intestinal bloating, which significantly contribute to neural mismatch along the gut-brain axis, manifesting as neuroinhibitory and motor dysregulatory effects between upper and lower gastrointestinal segments. (Open J Biomed Res 2026;5:43-46)